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09/12/2019 |
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08/07/2019 |
 Our work led by Hiro, Risa, together with excellent collaborators—Dr. Guowei Yin and Dr. Sharon Campbell, has been published! This is the first report that identify the lysine methylation of Ras and its potential impact on Ras activity! |
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08/01/2019 |
 Our work, led by Satoshi as the first author, has been published! Collaborating with fantastic researchers crossing countries enables the discovery. Our study unveil that specific upregulation of GTP biosynthesis by IMPDH2 drives rRNA and tRNA transcription and nucleolar hypertrophy and thereby the malignant growth of glioblastoma. We sincerely thank all collaborators and our supporters. |
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07/22/2019 |
 Collaboration work with Dr. Jin Cho's group has been published! The work unveil new linkage of phosphoinositide and spatio-tempora regulation of KRAS, the onco-protein mutated in over 20% of tumors. |
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06/26/2019 |
 Our work, lead by Hiro and Risa, has been accepted in PLOS ONE! Congratulations Hiro and Risa! |
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06/10/2019 |
 Kara's work has been published! The work has revealed unexpected, dynamic localization of purine nucleotide metabolic enzymes, pointing to spatio-temporal regulation of GTP metabolism in highly invasive cancers, and possible other migrating cell systems.
Congratulations, Kara, Satoshi, Hiro, Mika, and Koichi! |
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05/31/2019 |
 Kara's manuscript has been accepted by Biophys. Biol. Res. Commun! During the course of the work, Kara has made a lot of breakthrough in experiment as well as in concept. Congratulations, Kara! |
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04/08/2019 |
 Satoshi—now a tenure-track Assistant Professor in Hiroshima Univ—joined the GTP-Sasaki Lab in 2014, made many remarkable discoveries. One of his work is now accepted by Nature Cell Biology! Congratulations Satoshi! |
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04/05/2019 |
 Ha-chan (Hajime Tanaka), a highly motivated medical student from Hiroshima Univ, has joined to the GTP-Sasaki Lab with the hope to learn what the bench-side research—already engaging himself to the project deeply! |
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03/23/2019 |
 Seminar at the Niigata University! After the seminar, we toast by making "G"! |
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The Sasaki Lab places an emphasis on learning and career development. We have our own system through which team members provide feedback on each other’s project and presentation.
Five out of the six postdoctoral members have received fellowships — with three of them leading research projects as a PI and co-investigators after winning grants — and published their work in high-impact journals. All postdoctoral fellows who recently finished their degrees, obtained academic positions, including two assistant professorships in the U.S. and one assistant professorship in Japan.
Five out of the six postdoctoral members have received fellowships — with three of them leading research projects as a PI and co-investigators after winning grants — and published their work in high-impact journals. All postdoctoral fellows who recently finished their degrees, obtained academic positions, including two assistant professorships in the U.S. and one assistant professorship in Japan.
If you are interested in joining the process of building a top-notch laboratory—rather than joining an already established lab—we encourage you to take our lab seriously as candidate for your training place. We are looking forward to welcoming a new GTP-geek member. Our door is opened for highly motivated undergraduate students, graduate students and post-doctral fellows. Instruction of the application for a postdoctoral fellow position is here.
Atsuo T. Sasaki, Ph.D.
Associate Professor
University of Cincinnati College of Medicine
Project Professor
Institute of Advanced Biosciences, Keio University
Visiting Professor: Hiroshima University
Associate Professor
University of Cincinnati College of Medicine
Project Professor
Institute of Advanced Biosciences, Keio University
Visiting Professor: Hiroshima University
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Tel: | 513-558-2160 | |
Fax: | 513-558-6703 |
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Email: | atsuo.sasaki@uc.edu / sasaki29@ttck.keio.ac.jp | |||
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Address: | Vontz Center 1328 (office) / 1234 (lab) 3125 Eden Ave., Cincinnati, OH 45267-0508 |
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Welcome to the Sasaki Lab’s WebsiteThe Sasaki Lab represents a team of scientists dedicated to helping save lives through research on links between GTP metabolism and cancer. We recently discovered the existence of a GTP energy sensing kinase, which has the effect of propelling tumor growth, as published in Molecular Cell. We continue to investigate the mechanism of GTP metabolism to find how it can be used to help improve the quality of life for cancer patients.
Sasaki Lab’s "GTP" Way:
Geek: we investigate GTP, GTP and GTP!
Together: we work together!
Passion: abosolute requirement for success!
Curiosity and Collaboration Are Key Drivers of Innovation Atsuo Sasaki: When I was in second-grade, I wondered if the varying root lengths of plants near the beach had anything to do with soil conditions. I walked around the neighborhood with a shovel in my hand until I had enough samples to compare. The effort earned me my first junior science award from the city of Kure, Hiroshima.
The following year, I decided to find the fastest way to ignite a piece of paper using a magnifying glass. I learned silver paper would never burn. In third grade, I experimented with materials for a tin-can telephone so I could talk with my friend from 100 yards away. Both of these projects landed me Hiroshima’s special science awards and taught me being inquisitive and tenacious pays off.
It’s the same curiosity that drives me today as I and my research team explore the field of GTP metabolism, a new frontier in cancer research that we developed. At Sasaki Lab, we place the highest priority on discussions. Innovation happens when people share their “crazy” ideas, realize the significance of those ideas and begin working together to make them a reality.
I have a one-hour lab session every week in which all team members challenge each other to reach for the creativity that they have inside of them.
Copyright © 2016 The Sasaki Lab All Rights Reserved.