(Alumnus) Kazutaka Sumita, MD, PhD

 
1997-2001   Bachelor of Medicine(MD), Tokyo Medical and Dental University, Tokyo, Japan
2001-2002   Resident, Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan
2002-2003   Staff Neurosurgeon, National Disaster Medical Center, Tokyo, Japan
2003-2004   Staff Neurosurgeon, Tsuchiura General Hospital, Ibaraki, Japan
2004-2008   PhD course, Tokyo Medical and Dental University, Tokyo, Japan
2008-2012   Staff Neurosurgeon, Tsuchiura General Hospital, Ibaraki, Japan
2012- 2015          Postdoctoral fellow, University of Cincinnati, Brain Tumor Center 
2015-          Assistant Professor, Tokyo Medical and Dental University, Japan

Current Licensure and Certification
2001   M.D.
2007   Board certified Neurosurgeon by the Japan Neurosurgical Society
2008   Ph.D.
2010   Board certified Neuroendovascular surgeon by the Japanese Society
            for Neuroendovascular Therapy
 
Awards and Honors:
2005 Center of Excellence(COE) supported special Scholar, Tokyo Medical and Dental University
2006 Award for the best presentation by COE meeting of Tokyo Medical and Dental University
2011 Award for Contribution on Excellent Emergency Care, Tsuchiura Fire Departmet
 
Selection Peer-Reviewed Publications:
The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis. Mol Cell. 2016 Jan 21;61(2):187-98.

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis. J Biol Chem. 2014 Feb 14;289(7):3950-9. 

Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. J Biol Chem. 2013 Dec 27;288(52):36856-62

The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki AT, Aronow B, Warnick RE, Lawler S, Driscoll JJ.

 Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A.:A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One, 8(1):e54127,2013
 
Yijun Bao*, Kazutaka Sumita*, Takumi Kudo, Kanchanamala Withanage,    Kentaro Nakagawa, Mitsunobu Ikeda, Kikuo Ohno, Yunjie Wang, Yutaka Hata: Roles of manmalian sterile 20-like kinase 2-dependent phosphorylations of Mps one binder 1B in the activation of nuclear Dbf2-related kinases. Genes to Cells. 14:1369-1381,2009  *equal contribution
 
S Hirabayashi*, K Nakagawa*, K Sumita*, S Hidaka, T Kawai, M Ikeda,
A Kawata, K ohno and Y Hata;Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase1 regulation of NDR1 by MST2 and MOB1. Oncogene, 27:4281-4292, 2008 *equal contribution
 
Junko Iida, Hiroyoshi Ishizaki, Miki Okamoto-Tanaka, Akira Kawata,
Kazutaka Sumita, Shintaro Ohgake, Yuji Sato, Hiroshi Yorifuji, Nobuyuki Nukina, Kazumasa Ohashi, Kensaku Mizuno, Tomonari Tsutsumi, Akira Mizogushi, Jun Miyoshi, Yoshimi Takai, Yutaka Hata: Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites. Molecular and Cellular Biology, 27:4388-4405, 2007
 
Kazutaka Sumita, Yuji Sato, Junko Iida, Akira Kawata, Mamiko Hamano, Susumu Hirabayashi, Kikuo Ohno, Elior Peles, Yutaka Hata: Synaptic scaffolding molecule (S-SCAM) membrane-associated  Guanylate kinase with inverted organization (MAGI)-2 is associated with cell adhesion molecules at inhibitory synapses in rat hippocampal neurons. Journal of Neurochemistry, 100:154-166, 2007
 
 Akira Kawata, Junko Iida, Mitsunobu Ikeda, Yuji Sato, Hiroki Mori, Ai Kansaku,
Kazutaka Sumita, Naoyuki Fujiwara, Chiaki Rokukawa, Mamiko Hamano, Susumu Hirabayashi, Yutaka Hata; CIN85 is localizated at synapses and forms a comlex with S-SCAM via dendrin. Journal of Biochemistry, 139:931-939, 2006