PUBLICATIONS
| 1. | SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT. J Biochem. 2021 Jul 9:mvab077. doi: 10.1093/jb/mvab077. Epub ahead of print. PMID: 34244779. [In press] | (PubMed) |
| 2. | Mycophenolate Mofetil Hepatotoxicity Associated With Mitochondrial Abnormality in Liver Transplant Recipients and Mice. Warren M, Mitsinikos T, Yanni G, Sasaki M, Sasaki AT, Thomas D. J Pediatr Gastroenterol Nutr. 2021 Oct 1;73(4):463-470. doi: 10.1097/MPG.0000000000003171. PMID: 34016874. | (PubMed) (PDF) |
| 3. | Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification. Osaka N, Hirota Y, Ito D, Ikeda Y, Kamata R, Fujii Y, Chirasani VR, Campbell SL, Takeuchi K, Senda T, Sasaki AT*. Front Mol Biosci. 2021 Jul 8;8:707439. doi: 10.3389/fmolb.2021.707439. PMID: 34307463; PMCID: PMC8295990. | (PubMed) (PDF) |
| 4. | Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers. Takashima T, Taniyama D, Sakamoto N, Yasumoto M, Asai R, Hattori T, Honma R, Thang PQ, Ukai S, Maruyama R, Harada K, Kuraoka K, Tanabe K, Sasaki AT, Ohdan H, Morii E, Murai J, Yasui W. Br J Cancer. 2021 Jul;125(1):65-77. doi: 10.1038/s41416-021-01364-3. Epub 2021 Mar 30. PMID: 33785877; PMCID: PMC8257722. | (PubMed) (PDF) |
| 5. | TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers. Nakasuka F, Tabata S, Sakamoto T, Hirayama A, Ebi H, Yamada T, Umetsu K, Ohishi M, Ueno A, Goto H, Sugimoto M, Nishioka Y, Yamada Y, Tomita M, Sasaki AT, Yano S, Soga T. Commun Biol. 2021 Jun 24;4(1):782. doi: 10.1038/s42003-021-02323-7. PMID: 34168290; PMCID: PMC8225889. | (PubMed) (PDF) |
| 6. |
Integration of Molecular Analysis, Cutting-edge Mouse Genetic Models and Proton Therapy to Improve Outcomes for Glioma Patients
Soma Sengupta, Luke E. Pater, Daniel Pomeranz Krummel, Bruce J. Aronow, Yoshihisa Hirota, Timothy N. Phoenix, Atsuo T. Sasaki
In. Gliomas. Debinski W (Ed). Exon Publications, Brisbane, Australia. ISBN: 978-0-6450017-4-7. https://www.ncbi.nlm.nih.gov/books/NBK570700/ | (PubMed) (PDF) |
| 7. | Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma Matthew Garrett, Yuki Fujii, Natsuki Osaka, Doshun Ito, Yoshihisa Hirota, Atsuo T. Sasaki In. Gliomas. Debinski W (Ed). Exon Publications, Brisbane, Australia. ISBN: 978-0-6450017-4-7. https://www.ncbi.nlm.nih.gov/books/NBK570701/ | (PubMed) (PDF) |
| 8. | Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema Biplab Dasgupta, Yoshihisa Hirota, Yuki Fujii, Natsuki Osaka, Doshun Ito, David R. Plas, Atsuo T. Sasaki In. Gliomas. Debinski W (Ed). Exon Publications, Brisbane, Australia. ISBN: 978-0-6450017-4-7. https://www.ncbi.nlm.nih.gov/books/NBK570702/ | (PubMed) (PDF) |
| 9. | Reuse of Molecules for Glioblastoma Therapy Koehler A, Karve A, Desai P, Arbiser J, Plas DR, Qi X, Read RD, Sasaki AT, Gawali VS, Toukam DK, Bhattacharya D, Kallay L, Pomeranz Krummel DA, Sengupta S. Pharmaceuticals (Basel). 2021 Jan 28;14(2):99. doi: 10.3390/ph14020099. | (PubMed) (PDF) |
| 10. | Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells.
Wolfe K, Kamata R, Coutinho K, Inoue T, Sasaki AT.
Front Oncol. 2020 Nov 2;10:554272. doi: 10.3389/fonc.2020.554272. eCollection 2020.
| (PubMed) (PDF) |
| 11. | GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism Satoshi Kofuji and Atsuo T. Sasaki Journal of Biochemistry doi: 10.1093/jb/mvaa085. Online ahead of print. | (PubMed) (PDF) |
| 12. | Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT. Cancers (Basel). 2019 Sep 11;11(9). pii: E1346. doi: 10.3390/cancers11091346. | (PubMed) (PDF) |
| 13. | IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma Kofuji, S., Hirayama, A., Eberhardt, A., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S., Ban, Y., Asano, M., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., Deberardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H., and Sasaki, AT*. Nature Cell Biology volume 21, pages1003–1014 (2019) Link to the article: https://rdcu.be/bMHNW | (PubMed) (PDF) |
| 14. | Identification of lysine methylation in the core GTPase domain by GoMADScan.
Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT.
PLoS One. 2019 Aug 7;14(8):e0219436. doi: 10.1371/journal.pone.0219436.
| (PubMed) (PDF) |
| 15. | Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria
Taylor E. Miller, Karen M. Henkels, Mary Huddleston, Richard Salisbury, Saber M. Hussain, Atsuo T. Sasaki, Kwang-Jin Cho
Journal of Cell Science 2019 : jcs.231886 doi: 10.1242/jcs.231886 Published 22 July 2019
| (PubMed) |
| 16. | Dynamic Compartmentalization of Purine Nucleotide Metabolic Enzymes at Leading Edge in Highly Motile Renal Cell Carcinoma. Wolfe, K., Kofuji, S., Yoshino, H., Sasaki, M., Okumura, K., and Sasaki, AT*. Biophys. Biol. Res. Commun, Biochem Biophys Res Commun. 2019 Aug 13;516(1):50-56. doi: 10.1016/. | (PubMed) (PDF) |
| 17. |
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J.
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.
Cell. 2018 Jan 11;172(1-2):90-105
| (PubMed) (PDF) |
| 18. | Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell Rep. 2017 Feb 28;18(9):2088-2095 | (PubMed) (PDF) |
| 19. | Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL.
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
J Clin Invest. 2016 Nov 1;126(11):4088-4102. | (PubMed) (PDF) |
| 20. | Takeuchi K, Senda T, Sasaki AT. JIKKEN IGAKU (Experimental Medicine) 2016;34(9) | |
| 21. | Takeuchi K, Senda M, Lo YH, Kofuji S, Ikeda Y, Sasaki AT* and Senda T*. Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells. FEBS J. 2016 Apr 19. doi: 10.1111/febs.13739. *equal correspondence | (PubMed) (PDF) |
| 22. | Miki Senda, Takeru Hayashi, Masanori Hatakeyama, Koh Takeuchi, Atsuo T Sasaki, and Toshiya Senda. Use of multiple cryoprotectants to improve diffraction quality from protein crystals. Cryst. Growth Des. 16(3)1565-71. | (PDF) |
| 23. | Sasaki AT. Book Review. Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI) 2016;256(4) | |
| 24. | Sumita K, Lo YH, Takeuchi K, Senda M, Kofuji S, Ikeda Y, Terakawa J, Sasaki M, Yoshino H, Majd N, Zheng Y, Kahoud ER, Yokota T, Emerling BM, Asara JM, Ishida T, Locasale JW, Daikoku T, Anastasiou D, Senda T, Sasaki AT. The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis. Molecular Cell 2016; 61:1-12. *This paper is selected as “Featured Article” of the issue *Introduced on the web of CCHEMIE.DE, New Delhi Television, Genetic Engineering and Biotechnology News, UC health News, Science Mission, Drug Target Review and Science Dialy. *Featured in Sci. Signal. 26 Jan 2016:Vol. 9, Issue 412, pp. ec15 *Featured in Cancer Discovery January 21, 2016 *Recommended in F1000 Prime *Featured in IMSS news | (PubMed) (PDF) |
| 25. | Davis MI, Sasaki AT, Simeonov A. Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format. Methods Mol Biol. 2016;1376:1-9. | (PubMed) (PDF) |
| 26. | Sasaki AT. Finding your way. JIKKEN IGAKU (Experimental Medicine) 2015;33(19) | |
| 27. | Sasaki AT. Successful research. JIKKEN IGAKU (Experimental Medicine) 2015;33(18) | |
| 28. | Sasaki AT. How to get offer 2. JIKKEN IGAKU (Experimental Medicine) 2015;33(16) | |
| 29. | Sasaki AT. How to get offer. JIKKEN IGAKU (Experimental Medicine) 2015;33(14) | |
| 30. | Sasaki AT. How to find great laboratory. JIKKEN IGAKU (Experimental Medicine) 2015;33(13) | |
| 31. | Sasaki AT. The critical factors for making your decision. JIKKEN IGAKU (Experimental Medicine) 2015;33(11) | |
| 32. | Sasaki AT. Pros and Cons of studying abroad. JIKKEN IGAKU (Experimental Medicine) 2015;33(9) | |
| 33. | Sasaki AT. Why we need to go abroad for research. JIKKEN IGAKU (Experimental Medicine) 2015;33(8) | |
| 34. | Majd N, Sumita K, Yoshino H, Chen D, Terakawa J, Daikoku T, Kofuji S, Curry R, Wise-Draper T, Warnick RE, Guarnaschelli J and Sasaki AT. A Review of the Potential Utility of Mycophenolate Mofetil as a Cancer Therapeutic. Journal of Cancer Research 2014; 423401. | (PDF) |
| 35. | Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT. Degaradation of Activated K-Ras Orthologue via K-Ras Specific Lysine Residues is Required for Cytokinesis. J Biol Chem. 2014;289(7):3950-9. | (PubMed) (PDF) |
| 36. | Baker R, Wilkerson EM, Sumita K, Isom DG, Sasaki AT, Dohlman HG, Campbell SL. Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination. J Biol Chem. 2013;288(52):36856-62. | (PubMed) (PDF) |
| 37. | Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim H-S, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S & Cantley LC. Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors. Cell. 2013; 155:844. | (PubMed) (PDF) |
| 38. | Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki AT, Aronow B, Warnick RE, Lawler S, Driscoll JJ. The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis. Scientific Reports. 2013; 3:1. | (PubMed) (PDF) |
| 39. | Davis MI*, Sasaki AT*, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One. 2013; 8:e54. | (PubMed) (PDF) |
| 40. | Baker R, Lewis SM, Sasaki AT, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL. Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nat. Stru. Mol. Biol 2013;20: 46-52. *Featured in the Nat Rev Mol Cell Biol 2012 Dec 19. doi: 10.1038/nrm3500 *Featured in the Cell signalling: How monoubiquitylation keeps RAS active. | (PubMed) (PDF) |
| 41. | Fujimura K, Sasaki AT, Anderson P. Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules. Nucleic Acids Res. 2012;40: 8099-8110. | (PubMed) (PDF) |
| 42. | Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways. J. Cell Physiol. 2012;227(4):1709-20. | (PubMed) (PDF) |
| 43. | Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Elevation of PTEN Induces a Tumor-Suppressive Metabolic State. Cell. 2012; 149:49. | (PubMed) (PDF) |
| 44. | Sasaki AT. How mTORC1 tastes amino acid, leucine. JIKKEN-IGAKU, (Experimental Medicine) 2012; 30. | |
| 45. | Anastasiou D, Poulogiannis G, Asara JM, Bellinger G, Vander Heiden MG, Sasaki AT, Locasale JW and Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science. 2011; 334:1278. | (PubMed) (PDF) |
| 46. | Locasale JW, Grassian AR, Bass AJ, Heffron G, Metallo CM, Sharfi H, Sasaki AT, Anastasiou D, Vokes NI, Sasaki M, Ligon AH, Beroukhim R, Stephanopoulos G, Asara JM, Meyerson M, Wagner G, Brugge JS, Cantley LC and Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genet. 2011; 43:869-74. | (PubMed) (PDF) |
| 47. | Thou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC. A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metabolism. 2011; 13:476. *Featured article in this issue of Cell Metabolism *This paper was evaluated and selected by the Faculty of 1000 Biology member | (PubMed) (PDF) |
| 48. | Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Robinson D, Cao Q, Prensner, Wang R, Jing X, Fries DF, Asangani IA, Li Y, Cao X, Kumar-Sinha C, Kahoud ER, Omenn GS, Rubin MA, Reuter V, Palanisamy N, Varambally N, Cantley LC, and Chinnaiyan AM. Characterization of KRAS Rearrangements in Metastatic Prostate Cancer. Cancer Discovery. 2011; 1:33-41. *Come with spotlight in Cancer Discovery. 2011, 1: 12-13. | (PubMed) (PDF) |
| 49. | Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC. Ubiquitination of Ras enhances activation and facilitates binding to PI 3-Kinase and Raf. Science Signaling. 2011; 4:1. *Highlighted as the cover page and come with perspective Science Signaling. 2011;4:12. *This paper was evaluated and selected by the Faculty of 1000 Biology member | (PubMed) (PDF) |
| 50. | Charest PG, Shen Z, Lakoduc A, Sasaki AT, Briggs S, Firtel RA. A novel Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration. Dev. Cell. 2010; 18:737-479. | (PubMed) (PDF) |
| 51. | Sasaki AT, Firtel RA. Spatiotemporal Regulation of Ras-GTPases during chemotaxis. Methods. Mol. Biol. 2009;571:333-348. | |
| 52. | Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest. 2008; 118:3065-74. | (PubMed) (PDF) |
| 53. | Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K Sundheimer LW, Meili R, Devreotes PN, Firtel RA. G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. J. Cell Biol. 2007; 178:185-191. *Highlighted in J. Cell Biol. 2007; 178: 180. | (PubMed) (PDF) |
| 54. | Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA. Role of PI3 kinases in chemotaxis in dictyostelium. J Biol Chem. 2007; 283:11874-84. | (PubMed) (PDF) |
| 55. | Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A. Suppressor of cytokine signaling 1 in lymphocytes regulates the development of intestinal inflammation in mice. Gut. 2006; 55:212-9. | (PubMed) (PDF) |
| 56. | Sasaki AT, Firtel RA. Mechanism of directional sensing and leading edge formation during chemotaxis. JIKKEN-IGAKU, (Experimental Medicine). 2006; 24:1930-1936. | |
| 57. | Sasaki AT, Firtel RA. Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur. J. Cell Biol. 2006; 85:873-95. | (PubMed) (PDF) |
| 58. | Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR, Parent CA, Firtel RA. TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium. Mol Biol Cell. 2005; 16:4572-83. | (PubMed) (PDF) |
| 59. | Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura K, Nishimura J, Yoshimura A. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 2005; 8:855-7. | (PubMed) (PDF) |
| 60. | Meili R, Sasaki AT, Firtel RA. Rho Rocks PTEN. Nat Cell Biol. 2005; 7:334-335. | (PubMed) (PDF) |
| 61. | Sasaki AT, Firtel RA. Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Found Symp. 2005; 269:73-87. | (PubMed) |
| 62. | Sasaki AT, Chun C, Takeda K, Firtel RA. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol. 2004; 167:505-18. *This paper was evaluated and selected by the Faculty of 1000 Biology member | (PubMed) (PDF) |
| 63. | Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, Saito N. Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem Biophys Res Commun. 2004; 325:843-51. | (PubMed) (PDF) |
| 64. | Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A. Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells. J Biol Chem. 2004; 279:52543-51. | (PubMed) (PDF) |
| 65. | Inagaki-Ohara K, Chinen T, Matsuzaki G, Sasaki A, Sakamoto Y, Hiromatsu K, Nakamura-Uchiyama F, Nawa Y, Yoshimura A. Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. J Immunol. 2004; 173:1390-8. | (PubMed) (PDF) |
| 66. | Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol. 2003; 5:427-32. *Highlighted in Nat. Cell Biol. 2003 5: 377-379. | (PubMed) (PDF) |
| 67. | Sasaki A, Inagaki-Ohara K, Yoshida T, Yamanaka A, Sasaki M, Yasukawa H, Koromilas AE, Yoshimura A. The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6. J Biol Chem. 2003; 278:2432-6. | (PubMed) (PDF) |
| 68. | Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F. SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol Chem. 2003; 278:661-71. | (PubMed) (PDF) |
| 69. | Endo T, Sasaki A, Minoguchi M, Joo A, Yoshimura A. CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation. J Biochem. 2003; 133:109-13. | (PubMed) (PDF) |
| 70. | Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Cell Cycle. 2003; 2:281-282. | (PubMed) |
| 71. | Sasaki A, Endo T, Yoshimura A. Analysis of tyrosine kinase signaling by yeast Tri-hybrid system. JIKKEN-IGAKU, (Experimental Medicine). 2002:125-129. | (PubMed) |
| 72. | Sasaki A, Taketomi T, Wakioka T, Kato R, Yoshimura A. Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation. J Biol Chem. 2001; 276:36804-8. | (PubMed) (PDF) |
| 73. | Wakioka T*, Sasaki A*, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A. Spred is a Sprouty-related suppressor of Ras signalling. Nature. 2001;412:647-51. *These authours contributed equally to this work | (PubMed) (PDF) |
| 74. | Sporri B, Kovanen PE, Sasaki A, Yoshimura A, Leonard WJ. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood. 2001; 97:221-6. | (PubMed) (PDF) |
| 75. | Wakioka T, Sasaki A, Kato R, Yoshimura A. Spred and Sprouty, negative feed-back regulators for the Ras/MAP kinase pathway. JIKKEN-IGAKU, (Experimental Medicine). 2001; 19:2194-2197. | (PubMed) |
| 76. | Wakioka T, Sasaki A, Kato R, Yoshimura A. Spred and Sprouty, negative feed-back regulators for the Ras/MAP kinase pathway. SAIBO-KOGAKU (Cell Biology) . 2001; 20:1328-1330. | (PubMed) |
| 77. | Sasaki A, Yasukawa H, Shouda T, Kitamura T, Dikic I, Yoshimura A. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J Biol Chem. 2000; 275:29338-47. | (PubMed) (PDF) |
| 78. | Endo T, Sasaki A, Yoshimura A. Application of yeast Tri-hybrid system. Cellular Molecular Medicine. 2000; 1:282-285. | (PubMed) |
| 79. | Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol. 2000; 18:143-64. | (PubMed) |
| 80. | Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu M, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ. CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling. J Biol Chem. 1999; 274:30266-72. | (PubMed) (PDF) |
| 81. | Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. 1999; 98:617-27. | (PubMed) (PDF) |
| 82. | Sasaki A, Yasukawa H, Suzuki A, Kamizono S, Syoda T, Kinjyo I, Sasaki M, Johnston JA, Yoshimura A. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 1999; 4:339-51. | (PubMed) (PDF) |
| 83. | Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A. APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. Leukemia. 1999; 13:760-7. | (PubMed) (PDF) |
| 84. | Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999; 18:1309-20. | (PubMed) (PDF) |
| 85. | Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A. APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. Oncogene. 1999; 18:759-67. | (PubMed) (PDF) |
| 86. | Sasaki A, Endo T, Yoshimura A. Analysis of tyrosine kinase signaling by yeast Tri-hybrid system. JIKKEN-IGAKU, (Experimental Medicine) . 1999; 17:2579-2583. | (PubMed) |
| 87. | Yoshimura A, Sasaki A, Kinjyo I, Suzuki A. A Mechanisms of Negative regulation of Cytokine Signaling. SAISHIN IGAKU. 1999; 54:166-177. | (PubMed) |
| 88. | Suzuki R, Sakamoto H, Yasukawa H, Masuhara M, Wakioka T, Sasaki A, Yuge K, Komiya S, Inoue A, Yoshimura A. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene. 1998; 17:2271-8. | (PubMed) (PDF) |
| 89. | Sakamoto H, Sasaki A, Yoshimura A. Regulation of cytokine signaling by CIS family. JIKKEN-IGAKU, (Experimental Medicine) . 1998; 16:472-479. | (PubMed) |
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| 92. | Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A. Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun. 1997; 239:4 39-46. | (PubMed) (PDF) |
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