|Epigenetic Regulators & Therapeutic Susceptibility in Acute Myeloid Leukemia|
|Chong Chen, Ph.D., Research Fellow with the Cancer Biology and Genetics
Program at the Sloane-Ketering Cancer Center for will be presenting a Special
Seminar for the Cancer Biology Seminar Series on Thursday, June 2nd at 11:00am
in the Rieveschl Auditorium at the Vontz Center for Molecular Studies. Dr.
Chen is a faculty Candidate in the Department of Cancer Biology. Dr. Chen
develops animal models of acute myeloid leukemia for preclinical studies and
to understand molecular mechanisms governing the is disease. In particular,
his work has focused on genetic alterations effecting epigenetic regulators,
which are commonly observed AML. He created the first mutant IDH-driven
leukemia model and demonstrated that IDH mutants are required for tumor
maintenance. Moreover, he also identified the first tumor suppressor on a
frequently deleted region of chromosome 7q in AML. Currently he is using
these genetically defined models to identify therapeutic targets in AML using
RNAi library screening. The title of Dr. Chen's seminar is "Epigenetic
Regulators & Therapeutic Susceptibility in Acute Myeloid Leukemia".